Cututtukan autoimmune, waɗanda ke da nau'ikan iri daban-daban kuma galibi suna da raɗaɗi da cututtuka masu tsanani, ɗaya daga cikin mahimman hanyoyin haɓaka magunguna na yanzu.JAK-STAT yana ɗaya daga cikin ƙananan hanyoyin rigakafi waɗanda aka tabbatar, musamman masu hana JAK.Magunguna da yawa,kamar tofacitinib, an tallata su a duk duniya.

An samar da manufar JAK kasa da shekaru 20, amma a halin yanzu an amince da kusan iri 7 don tallatawa.Alamomin sun fi ciwace-ciwacen ciwace-ciwacen daji da cututtukan da ke da alaƙa da kai, kuma ƙarin abubuwan da aka gyara sun haɗa da fibrosis na kasusuwa da rheumatoid amosanin gabbai.Wadannan suna mayar da hankali ga mai hanawa na JAK na farko (tofacitinib) don maganin cututtuka na rheumatoid.

Tofacitinib wani ƙananan ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta JAK ta Pfizer ta haɓaka.Yana da kyakkyawan zaɓi na JAK.A cikin Nuwamba 2012, US FDA ta amince da tofacitinib citrate don maganin methotrexate rashin isa ko rashin haƙuri ga magani.Wannan samfurin shine farkon mai hanawa na JAK wanda FDA ta amince da shi don maganin cututtukan cututtuka na rheumatoid.A halin yanzu, ban da alamun da aka yarda da su, ana kuma gwada tofacitinib don ingancinsa a cikin spondylitis na ankylosing, atopic dermatitis, keratoconjunctivitis sicca da cutar Crohn.Dangane da tallace-tallace na duniya, tallace-tallace na shekara-shekara na tofacitinib a cikin 2017 ya haura dalar Amurka biliyan 1, kuma tallace-tallace na shekara-shekara a 2019 ya kai dala biliyan 2.242.

Hanyoyi daban-daban na roba za su yi tasiri sosai kan yawan amfanin ƙasa da ingancin APIs.Haɗin mu na tofacitinib citrate yana guje wa hanyar da aka ƙera.Hanyar roba tana buƙatar ƙananan farashin albarkatun ƙasa, yawan amfanin ƙasa, ƙazanta guda ɗaya da tsafta ana iya sarrafa su a cikin kewayon da ya dace, ko abokan ciniki na iya keɓance su.Don haka ba mu damar samun fa'ida a kasuwa.A halin yanzu karfin mu na iya zama 50kg a kowane wata, kuma an riga an fitar da tofacitinib citrate zuwa Amurka, Mexico, Franch, Bangladesh, da sauransu.